Triamterene / HCTZ Online


Buy Dyazide (Triamterene/Hydrochlorothiazide) antihypertensive drug and diuretic
Cheap qualitative Triamterene plus HCTZ 50 mg / 25 mg tablets or capsules online



HOW AND WHERE TO BUY DYAZIDE (TRIAMTERENE, HYDROCHLOROTHIAZIDE) 50 MG / 25 MG TABLETS OR CAPSULES ONLINE:


PHARMA SHOP

Lowest prices
Good quality
from $0.95 per pill
10% discount coupon: hf-5478



DRUGS FOR HEALTH

Low prices
High quality
from $1.01 per pill
5% discount coupon: A1XKPKC



DISCOUNT MEDS

Average prices
Best quality
from $1.24 per pill
5% discount coupon: dmeds5


For more offers please visit
PHARMA DOCTOR: TRIAMTERENE, HYDROCHLOROTHIAZIDE



DYAZIDE (TRIAMTERENE, HYDROCHLOROTHIAZIDE) CAPSULES: NONCLINICAL TOXICOLOGY

Carcinogenesis, Mutagenesis, Impairment of Fertility

Carcinogenesis

Long-term studies have not been conducted with Dyazide (Triamterene plus HCTZ) capsules, or with triamterene alone.

Hydrochlorothiazide

Two-year feeding studies in mice and rats, conducted under the auspices of the National Toxicology Program (NTP), treated mice and rats with doses of hydrochlorothiazide up to 600 and 100 mg/kg/day, respectively. On a body-weight basis, these doses are 600 times (in mice) and 100 times (in rats) the Maximum Recommended Human Dose (MRHD) for the hydrochlorothiazide component of Dyazide at 50 mg/day (or 1.0 mg/kg/day based on 50 kg individuals). On the basis of body-surface area, these doses are 56 times (in mice) and 21 times (in rats) the MRHD. These studies uncovered no evidence of carcinogenic potential of hydrochlorothiazide in rats or female mice, but there was equivocal evidence of hepatocarcinogenicity in male mice.

Mutagenesis

Studies of the mutagenic potential of Dyazide (Triamterene with Hydrochlorothiazide), or of triamterene alone have not been performed.

Hydrochlorothiazide

Hydrochlorothiazide was not genotoxic in in vitro assays using strains TA 98, TA 100, TA 1535, TA 1537 and TA 1538 of Salmonella typhimurium (the Ames test); in the Chinese Hamster Ovary (CHO) test for chromosomal aberrations; or in in vivo assays using mouse germinal cell chromosomes, Chinese hamster bone marrow chromosomes, and the Drosophila sex-linked recessive lethal trait gene. Positive test results were obtained in the in vitro CHO Sister Chromatid Exchange (clastogenicity) test, and in the mouse Lymphoma Cell (mutagenicity) assays, using concentrations of hydrochlorothiazide of 43 to 1300 mcg/mL. Positive test results were also obtained in the Aspergillus nidulans nondisjunction assay, using an unspecified concentration of hydrochlorothiazide.

Impairment of Fertility

Studies of the effects of Dyazide (the triamterene/hydrochlorothiazide combination), or of triamterene alone on animal reproductive function have not been conducted.

Hydrochlorothiazide

Hydrochlorothiazide had no adverse effects on the fertility of mice and rats of either sex in studies wherein these species were exposed, via their diet, to doses of up to 100 and 4 mg/kg/day, respectively, prior to mating and throughout gestation. Corresponding multiples of the MRHD are 100 (mice) and 4 (rats) on the basis of body-weight and 9.4 (mice) and 0.8 (rats) on the basis of body-surface area.

Recent posts:

  • Buy Dyazide (Triamterene/HCTZ) Online
  • Dyazide prescribing information



    Copyright © 2016-2019 Triamterene-Hydrochlorothiazide.cheapmeddrugs.org, a division of Pharma-Doctor.com pharmaceutical network.

    Home Page | Privacy Policy | Cookies Policy | Terms of Service | Contact Us