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DYAZIDE (TRIAMTERENE, HYDROCHLOROTHIAZIDE) CAPSULES: ADVERSE REACTIONS / SIDE EFFECTS
Adverse effects are listed in decreasing order of severity.
Hypersensitivity: rash, anaphylaxis, urticaria, subacute cutaneous lupus erythematosus-like reactions, photosensitivity.
Cardiovascular: postural hypotension, arrhythmia.
Metabolic: hyperkalemia, diabetes mellitus, hypokalemia, hyponatremia, acidosis, hyperglycemia, hypercalcemia, glycosuria, hypochloremia, hyperuricemia.
Gastrointestinal: jaundice and/or liver enzyme abnormalities, nausea, vomiting, pancreatitis, diarrhea, abdominal pain, constipation.
Renal: acute renal failure (one case of irreversible renal failure has been reported), renal stones composed primarily of triamterene, interstitial nephritis, elevated BUN, and serum creatinine, abnormal urinary sediment.
Hematologic: thrombocytopenia and purpura, leukopenia, megaloblastic anemia.
Musculoskeletal: muscle cramps.
Central Nervous System: fatigue, weakness, dizziness, headache, dry mouth.
Miscellaneous: sialadenitis, impotence.
Thiazides alone have been shown to cause the following additional adverse reactions:
Central Nervous System: vertigo, paresthesias.
Ophthalmic: transient blurred vision, xanthopsia.
Respiratory: pulmonary edema, allergic pneumonitis, respiratory distress.
Other: necrotizing vasculitis, exacerbation of lupus.
Hematologic: agranulocytosis, aplastic anemia, hemolytic anemia.
Neonate and infancy: thrombocytopenia and pancreatitis-rarely, in newborns whose mothers have received thiazides during pregnancy.
Skin: erythema multiforme including Stevens-Johnson syndrome, exfoliative dermatitis including toxic epidermal necrolysis.
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