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DYAZIDE (TRIAMTERENE, HYDROCHLOROTHIAZIDE) CAPSULES: ADVERSE REACTIONS / SIDE EFFECTS

Adverse effects are listed in decreasing order of severity.

Hypersensitivity: rash, anaphylaxis, urticaria, subacute cutaneous lupus erythematosus-like reactions, photosensitivity.

Cardiovascular: postural hypotension, arrhythmia.

Metabolic: hyperkalemia, diabetes mellitus, hypokalemia, hyponatremia, acidosis, hyperglycemia, hypercalcemia, glycosuria, hypochloremia, hyperuricemia.

Gastrointestinal: jaundice and/or liver enzyme abnormalities, nausea, vomiting, pancreatitis, diarrhea, abdominal pain, constipation.

Renal: acute renal failure (one case of irreversible renal failure has been reported), renal stones composed primarily of triamterene, interstitial nephritis, elevated BUN, and serum creatinine, abnormal urinary sediment.

Hematologic: thrombocytopenia and purpura, leukopenia, megaloblastic anemia.

Musculoskeletal: muscle cramps.

Central Nervous System: fatigue, weakness, dizziness, headache, dry mouth.

Miscellaneous: sialadenitis, impotence.

Thiazides alone have been shown to cause the following additional adverse reactions:

Central Nervous System: vertigo, paresthesias.

Ophthalmic: transient blurred vision, xanthopsia.

Respiratory: pulmonary edema, allergic pneumonitis, respiratory distress.

Other: necrotizing vasculitis, exacerbation of lupus.

Hematologic: agranulocytosis, aplastic anemia, hemolytic anemia.

Neonate and infancy: thrombocytopenia and pancreatitis-rarely, in newborns whose mothers have received thiazides during pregnancy.

Skin: erythema multiforme including Stevens-Johnson syndrome, exfoliative dermatitis including toxic epidermal necrolysis.

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